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In a further embodiment, trade name for hydrochlorothiazide p is a single bond; X is CR 6R 6′; R 6 is alkyl; R 6′ is hydrogen; R 5 is hydroxyl; R 7 and R 8 are each hydrogen and R 10 is hydroxyl. In standard methods, reducing hydrochlorothiazide dosage observing X = 2 would be undiagnostic, since it is not in a sensible tail rejection interval (or region) for either hypothesis.

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